Elucidating evolutionarily conserved mechanisms of diapause regulation using an in silico approach

Embryonic diapause is an enigmatic phenomenon that appears in diverse species. Although regulatory mechanisms have been established, there much to be discovered. Herein, we made the first comprehensive attempt elucidate using a computational approach. We found transcription factors unique promoters of genes From pathway analysis and STRING PPI networks, signaling pathways regulated by these were identified. The then consolidated into model combine various known regulation. This work also highlighted certain may act as ‘master factors’ regulate phenomenon. Promoter further suggested evidence for independent evolution some elements involved diapause.